Comparing Intensive Versus Standard Blood Sugar Targets in Overweight and Obese Pregnant Women with Gestational Diabetes to Improve Pregnancy Outcomes

What this Trial Is About

Researchers are studying overweight and obese pregnant women diagnosed with gestational diabetes to compare two different blood sugar control targets. This trial aims to see if tighter blood sugar control improves outcomes for mothers and their babies without increasing risks. The study is a large, randomized clinical trial conducted at multiple centers across the U.S. involving 828 women. Participants are randomly assigned to one of two groups one group will aim for intensive blood sugar targets with fasting levels below 90 mgdL and one-hour post-meal levels below 120 mgdL, while the other group will follow standard targets with fasting levels below 95 mgdL and one-hour post-meal levels below 140 mgdL. The study team will monitor blood sugar control and pregnancy outcomes throughout the pregnancy period. Women in the study will have their blood sugar levels regularly checked and monitored from the time of enrollment until delivery. Researchers will assess key outcomes including newborn health issues within a week of delivery, birth weight, maternal blood sugar control, hypoglycemia episodes, and pregnancy complications. The total participation lasts from gestational weeks 12 to 33, with follow-up through delivery and shortly after to evaluate both mother and infant health.

Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes