Functional and Neurodevelopmental Outcomes Following Intensive Multimodal Neurorehabilitation in Pediatric Patients With Neurodevelopmental Disorders, Including Chromosomal Abnormalities

What this Trial Is About

This research aims to observe the functional and developmental outcomes in children with neurodevelopmental disorders undergoing an intensive multimodal neurorehabilitation program. It focuses on pediatric participants aged approximately 4 to 12 years with conditions such as cerebral palsy, autism spectrum disorder, developmental delay, hypoxic ischemic encephalopathy, traumatic brain injury, and genetic or chromosomal abnormalities. The study seeks to understand the potential benefits of intensive therapy approaches on various neurodevelopmental domains. Participants attend individualized therapy sessions for about 2.5 hours per day, five days a week, over two consecutive weeks. The therapy is tailored to each child's needs and may include sensory integration, motor planning, reflex integration, oculomotor training, auditory processing, executive functioning tasks, communication support, emotional regulation training, and other neurodevelopmental exercises. Additional treatments like vibration, tactile stimulation, and photobiomodulation may be used based on clinician discretion. Throughout the study, clinicians assess changes in functional neurodevelopmental performance from baseline to the end of the two-week program, including attention, motor coordination, emotional regulation, communication, and daily living activities. Parent-reported outcomes on functional improvements and retention of gains are collected up to four weeks after the program. This observational study collects real-world data from children already enrolled in the therapy program without assigning specific treatments as part of the research.

Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders