Actively Recruiting
Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy
Led by Assistance Publique Hopitaux De Marseille · Updated on 2024-07-18
214
Participants Needed
12
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis. The primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.
CONDITIONS
Official Title
Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient 16 years of age and older
- Epileptogenic area involves temporal structures of the language-specialized hemisphere
- Known hemispheric specialization for language
- Planned resective surgery in temporal lobe compatible with study schedule
- Known neuropsychological test (NTB) score
- Signed informed consent by patient or legal guardian
- First language is French
- Familiar with computer use and has home internet access
- Affiliated with or benefiting from a social security system
You will not qualify if you...
- Speech disorder impairing intelligibility and use of the interface
- Uncorrected hearing impairment
- Total IQ below 70 measured within the year before surgery
- Pregnant or nursing
- Deprived of liberty or under guardianship or curatorship
AI-Screening
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Trial Site Locations
Total: 12 locations
1
Service EFSN - Hôpital Pellegrin
Bordeaux, France
Actively Recruiting
2
Service de Neurologie de l'Epilepsie - CHU Grenoble-Alpes
Grenoble, France
Actively Recruiting
3
Département de Neurophysiologie Clinique - Hôpital Roger Salengro - CHU Lille
Lille, France
Actively Recruiting
4
Hôpital Neurologique Pierre Wertheimer- Service de Neurologie Fonctionnelle et Epileptologie - Hospices Civils Lyon
Lyon, France
Not Yet Recruiting
5
Service Epilptologie et Rythmologie Cérébrale
Marseille, France
Actively Recruiting
6
Service de Neurologie - Hôpital central -CHU Nancy
Nancy, France
Not Yet Recruiting
7
Département de Neurologie - Hôpital de la Pitié-Salpêtrière - APHP
Paris, France
Not Yet Recruiting
8
Service de Neurochirurgie -GHU Sainte-Anne
Paris, France
Not Yet Recruiting
9
Service de Neurologie - Fondation ophtalmologique de Rothschild - Fondation Rothschild
Paris, France
Actively Recruiting
10
Service de Neurologie - CHU de Rennes
Rennes, France
Not Yet Recruiting
11
Service de Neurologie - Hôpitaux Universitaires, Hôpital de Hautepierre
Strasbourg, France
Actively Recruiting
12
Explorations Neurophysiologiques, Pôle des Neurosciences - Hôpital Pierre Paul Riquet, Purpan
Toulouse, France
Not Yet Recruiting
Research Team
V
Veronique Sabadell
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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