Actively Recruiting
Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder
Led by Karolinska Institutet · Updated on 2026-04-07
140
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
R
Region Stockholm
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare a novel, massed treatment format of prolonged exposure to gold standard trauma focused cognitive behavioral therapy (weekly delivered prolonged exposure) for post-traumatic stress disorder. The objective with this study is to investigate efficacy, mechanisms of change and cost effectiveness of intensive prolonged exposure (I-PE) in regular Swedish psychiatric care. Adult patients with post-traumatic stress disorder will be randomly assigned to receive either gold standard prolonged exposure weekly for 15 weeks or 5 days of intensive treatment with the addition of three booster sessions dispersed 1, 2 and 4 weeks after completion of the massed treatment period. Qualitative interviews will be conducted with therapists to explore their experiences of delivering intensive treatment for PTSD, with particular focus on perceived benefits and challenges, clinical processes, patient engagement, and the impact of the intensive format on therapeutic work.
CONDITIONS
Official Title
Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or above
- Primary PTSD diagnosis
- Fluent in Swedish
- Signed informed consent
- Able to attend either intensive prolonged exposure or 15 weekly prolonged exposure sessions
You will not qualify if you...
- Started or changed psychotropic medication within 4 weeks before treatment
- Serious mental health symptoms such as mania, psychosis, substance use disorders, or current suicide risk needing immediate care
- Currently receiving evidence-based trauma-focused psychological treatment
- Ongoing trauma-related threat, such as living with a violent spouse
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Traumaprogrammet, Psykiatri Sydväst
Stockholm, Sweden
Actively Recruiting
Research Team
M
Maria Bragesjö, PhD
CONTACT
H
Hannes Hedvall, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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