Actively Recruiting
The Efficacy of Continuous Intercostal Nerve Blocks in the Treatment of Patients With Multiple Rib Fractures
Led by Zachary Warriner · Updated on 2025-10-07
180
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of continuous intercostal nerve block (CINB) alongside standard medical therapy compared to standard medical care alone for adults with multiple rib fractures. The study aims to analyze the effect of CINB in patients admitted to the adult trauma service, focusing on its role as an additional treatment to nonsteroidal and opioid medications. This is a randomized, non-blinded Phase 4 study investigating the effectiveness of CINB in this setting. Participants in the study are assigned to receive either CINB with continuous local intercostal infusion of 0.2% Ropivacaine or standard medical care involving nonsteroidal anti-inflammatory drugs and opioid pain medications given intravenously or orally. For CINB, one or two catheters are placed depending on the area involved, and treatment may continue after hospital discharge as part of standard care. The standard care group receives pain medications per usual hospital protocols. During the study, researchers will monitor participants over 7 days for outcomes such as length of hospital stay, daily pain scores, morphine use, respiratory measures, and patient-reported quality of life. Hospital-free days will also be assessed up to 30 days. The study collects various clinical data to compare the effectiveness of CINB plus medical therapy versus standard care alone in managing rib fracture pain and recovery.
CONDITIONS
Brief Title
INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects will be at least 18 years old
- Subjects will have 2 or more identified rib fractures
- Subjects will be willing to provide informed consent for procedure
- Subjects will be identified as appropriate for initiation of continuous nerve block therapy for treatment of rib fracture associated pain.
You will not qualify if you...
- Documented allergy to study medication
- Epidural catheter use
- Prisoners
- Refusal of CINB therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 7 days
Participants receive either continuous intercostal nerve block therapy with Ropivacaine or standard medical care including nonsteroidal anti-inflammatory drugs and opioids for pain management of rib fractures.
Daily visits during hospital stay
Trial Site Locations
Total: 1 location
1
University of Kentucky Medical Center
Lexington, Kentucky, United States, 40536
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here