Actively Recruiting
Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer
Led by University Hospital, Rouen · Updated on 2026-05-12
188
Participants Needed
14
Research Sites
227 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the efficacy of erectile rehabilitation with Sildenafil, in men treated with neoadjuvant proctectomy and radiotherapy for rectal cancer, in preventing long-term erectile dysfunction at 12 months post-operatively.
CONDITIONS
Official Title
Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male aged 18 to 70 years
- Undergoing total mesorectal excision surgery for lower or middle rectal cancer after neoadjuvant radiotherapy
- Normal erectile function before surgery (IIEF erectile function domain score of at least 22)
- Surgery includes nerve-conserving techniques
- Sexually active without prior erectile dysfunction treatment
- Has a regular sexual partner (male or female)
- Adult able to understand study information and provide consent
- Enrolled in a social security scheme
You will not qualify if you...
- Tumor classified as T4 or requiring extended surgery
- Abnormal erectile function before surgery (IIEF erectile function domain score less than 22)
- History of prostate cancer
- Sleep disorders or use of sedatives/hypnotics
- Contraindications to Sildenafil 50 mg or placebo
- Current treatment with PDE5 inhibitors
- Infection with SARS-CoV-2
- Legal restrictions or guardianship preventing consent
- Psychological or sensory conditions impairing understanding or consent
- Participation in another drug trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Chu Amiens
Amiens, France, 80054
Actively Recruiting
2
Hopital Beauvais
Beauvais, France, 60000
Actively Recruiting
3
Chu Besancon
Besançon, France, 25030
Actively Recruiting
4
Aphp Bicetre
Bicêtre, France, 94275
Actively Recruiting
5
Chu Bordeaux
Bordeaux, France, 33000
Actively Recruiting
6
Institut Bordeaux Colorectal
Bordeaux, France, 33000
Actively Recruiting
7
Chu Clermont-Ferrand
Clermont-Ferrand, France, 63000
Actively Recruiting
8
Chu Lille
Lille, France, 59000
Actively Recruiting
9
Institut Paoli-Calmettes
Marseille, France, 13009
Actively Recruiting
10
Institut Du Cancer Montpellier
Montpellier, France, 34000
Actively Recruiting
11
Aphp St Antoine
Paris, France, 75012
Actively Recruiting
12
Aphp Hegp
Paris, France, 75908
Actively Recruiting
13
Chu Rouen
Rouen, France, 76031
Actively Recruiting
14
Chu Tours
Tours, France, 37000
Actively Recruiting
Research Team
V
Valérie Bridoux
CONTACT
J
Julie Rondeaux, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here