Interest of Individual Biomarkers From the Identification of Tumor Genotype in Plasma (ctDNA) by High-throughput Molecular Next Generation Techniques in the Diagnosis and Management of Lymphomas

What this Trial Is About

Lymphomas are the most common blood cancers, with diffuse large B-cell lymphoma (DLBCL), Hodgkin's lymphoma (HL), and follicular lymphoma (FL) being the three most frequent types. Treatments for these lymphomas often aim to cure. Positron emission tomography (PET) is currently used to guide treatment by balancing effectiveness and side effects, adjusting treatment intensity based on patient response. Researchers are exploring additional methods, such as circulating tumor DNA (ctDNA) analysis using advanced sequencing techniques, to better characterize lymphoma before and during treatment and to improve patient management. This study collects plasma samples from patients diagnosed with one of the common lymphomas before treatment, during therapy, and for two years afterward. It focuses on identifying tumor DNA in the blood using high-throughput molecular techniques like CAPP-Seq, PhAsE Seq, and VIRCAPP-seq. The goal is to evaluate whether monitoring ctDNA alongside PET scans can help tailor treatment more precisely, detect relapses earlier, and manage patients with poor responses more effectively. The study also includes less common lymphoma subtypes such as mantle cell lymphoma and T-cell lymphoma. Participants will provide blood samples at various points throughout their treatment and follow-up period, which averages seven years. Researchers will analyze these samples to track biomarkers and tumor mutation profiles over time. The study monitors patients without altering their prescribed treatment plans and aims to gather data that may inform personalized lymphoma management in the future. The trial is non-randomized and observational in nature, focusing on long-term biomarker evaluation and patient outcomes.

Interest of Individual Biomarkers From the Identification of Tumor Genotype by High-throughput Molecular Techniques