Actively Recruiting
Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination
Led by University Hospital, Toulouse · Updated on 2026-05-05
692
Participants Needed
4
Research Sites
168 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Intrauterine insemination (IUI) is a common therapeutic option to treate infertility. Typically performed 36 hours post-hCG injection to trigger ovulation. However, research suggests delaying IUI to 42 hours post-hCG may improve egg quality and sperm synchronization for fertilization, leading to higher pregnancy rates. A proposed superiority study aims to compare IUI timing at 36 hours versus 42 hours post-hCG injection to evaluate its impact on live birth rates. The primary objective is to assess the effectiveness (live birth rates) of IUI at two different post-hCG timing intervals (42-43 hours vs 36-37 hours).
CONDITIONS
Official Title
Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Single unmarried woman or heterosexual or homosexual couple where the woman is aged 18 to 43 and the spouse is aged 18 to 60 at inclusion
- Two open (permeable) fallopian tubes in the woman receiving insemination
- Use of spouse's sperm with at least 1 million inseminable sperm or sperm donation
- First or second intrauterine insemination for this child project
- Ovarian stimulation with gonadotropins and GnRH antagonist
- Luteal phase support with a progestin until at least the pregnancy test
- Affiliation or beneficiary of social security or equivalent for both partners if applicable
- Signed free and informed consent by the unmarried woman or both members of the couple
- Couples and unmarried women meeting French bioethics law conditions for assisted reproduction access
You will not qualify if you...
- Endometriosis stage III or IV
- History of ectopic pregnancy
- Three or more spontaneous miscarriages
- Single woman or couple where one or both partners are under legal protection such as guardianship or curatorship
- Single woman or couple who have already participated in this study once
- Single woman or couple currently participating in another interventional clinical study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
CHU Bordeaux
Bordeaux, France
Not Yet Recruiting
2
CHU La Réunion
La Réunion, France
Not Yet Recruiting
3
CHU Poitiers
Poitiers, France
Not Yet Recruiting
4
CHU Toulouse
Toulouse, France
Actively Recruiting
Research Team
J
Jessika MOREAU, MD
CONTACT
C
Celia BETTIOL, CRA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here