Actively Recruiting
Interferon Pathway Activation in Monogenic and Nonmonogenic Forms of Pediatric SLE
Led by Meyer Children's Hospital IRCCS · Updated on 2024-09-19
60
Participants Needed
3
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pediatric SLE includes monogenic forms, some of which involve the interferon type I (IFN-I) pathway. The IFN-I pathway is renally active in adult SLE and correlates with the extent of renal damage. In pediatric SLE, and particularly in lupus nephritis, activation of the IFN-I pathway has never been studied, nor is it known whether monogenic forms underlie more pronounced interferon activation.
CONDITIONS
Official Title
Interferon Pathway Activation in Monogenic and Nonmonogenic Forms of Pediatric SLE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of systemic lupus erythematosus before age 18 according to SLICC and/or EULAR 2019 criteria
- Clinical, laboratory, or histologic evidence of kidney involvement before age 18
- Signed informed consent
You will not qualify if you...
- Kidney disease beginning after age 18
- Lupus caused by drugs or linked with diseases like systemic sclerosis, rheumatoid arthritis, Sjögren's syndrome, or other connective tissue diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Meyer Children's Hospital IRCCS
Florence, Italy
Actively Recruiting
2
IRCCS Gianna Gaslini
Genova, Italy
Actively Recruiting
3
IRCCS Humanitas Research Hospital
Rozzano, Italy
Actively Recruiting
Research Team
C
Carmela Errichiello, MD
CONTACT
C
Carmela Errichiello, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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