Actively Recruiting
Reference Values Determination of Nasal and Blood Interferon Scores in Uninfected Older Subjects REFérence Interféron Older Subjects (Older People Interferon Reference) - REFIPA Study
Led by Hospices Civils de Lyon · Updated on 2026-04-08
62
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how to better diagnose respiratory viral infections in older adults by studying the body's immune response, specifically the production of type I interferons (IFN-I). Current PCR tests have limitations, such as testing only a few viruses and detecting viral material even after infections end. Since older people experience changes in immune function, including reduced IFN-I production, this study aims to establish baseline IFN scores in uninfected older individuals to improve interpretation of diagnostic tests. Participants in this study are uninfected adults aged 80 years and older. Each participant will attend a single visit during which a nasopharyngeal swab will be taken to measure nasal IFN scores and test for infection. Blood samples totaling 32 mL will also be collected to measure blood IFN scores, analyze anti-IFN antibody levels, and assess lymphocyte subtypes. Leftover biological samples may be stored with consent for further research. During the visit, researchers will assess nasal and blood IFN-I scores and correlate them with clinical measures of health, such as frailty and comorbidities. These assessments will help define reference values for IFN responses in older adults. The study involves only one visit, and all measurements will be taken during this time. Participants' usual care continues independently, and the study is expected to end in late 2026.
CONDITIONS
Brief Title
Interferon Reference for Older People - REFIPA Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subject aged 80 or over
- Patient admitted to the Charpennes hospital day unit or outpatient clinic for follow-up OR accompanying patient who receives care at the Charpennes geriatric hospital OR subject recruited through the local press
- Weight greater than or equal to 45 kg
- Subject living in the Lyon metropolitan area
You will not qualify if you...
- Subjects with symptoms of active infection (symptom questionnaire or temperature > 37.5�B0C)
- Subjects with an autoimmune disease linked to a dysregulated interferon response
- Subjects participating in another interventional study involving an exclusion period that is still ongoing or that may interfere with the present protocol
- Subjects deprived of their liberty by judicial or administrative decision
- Subjects receiving psychiatric care
- Adults subject to legal protection measures (guardianship, curatorship)
- Subjects not affiliated with a social security scheme or beneficiaries of a similar scheme
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Hôpital des Charpennes (Hospices Civils de Lyon)
Villeurbanne, France, 69100
Actively Recruiting
Research Team
A
Antoine GARNIER-CRUSSARD
S
Sophie TROUILLET-ASSANT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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