Measuring Nasal and Blood Interferon Levels in Uninfected Older Adults Aged 80 and Above to Establish Reference Values

What this Trial Is About

Researchers are evaluating how to better diagnose respiratory viral infections in older adults by studying the bodys immune response, specifically the production of type I interferons IFN-I. Current PCR tests have limitations, such as testing only a few viruses and detecting viral material even after infections end. Since older people experience changes in immune function, including reduced IFN-I production, this study aims to establish baseline IFN scores in uninfected older individuals to improve interpretation of diagnostic tests. Participants in this study are uninfected adults aged 80 years and older. Each participant will attend a single visit during which a nasopharyngeal swab will be taken to measure nasal IFN scores and test for infection. Blood samples totaling 32 mL will also be collected to measure blood IFN scores, analyze anti-IFN antibody levels, and assess lymphocyte subtypes. Leftover biological samples may be stored with consent for further research. During the visit, researchers will assess nasal and blood IFN-I scores and correlate them with clinical measures of health, such as frailty and comorbidities. These assessments will help define reference values for IFN responses in older adults. The study involves only one visit, and all measurements will be taken during this time. Participants usual care continues independently, and the study is expected to end in late 2026.

Interferon Reference for Older People - REFIPA Study