Actively Recruiting
Interleaved TMS-fMRI in Ultra-treatment Resistant Depression
Led by Sunnybrook Health Sciences Centre · Updated on 2024-11-15
88
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a study that will recruit patients from the neurosurgery clinic and the regular TMS clinic. It's a smaller study designed to collect brain imaging pre-treatment and then use image guided TMS to treat patient with a one week "accelerated" rTMS protocol using the research TMS machine that is housed in Dr. Sean Nestor's lab. The idea is to examine whether severe treatment resistant depression has a different brain signature than less severe/TRD and whether the investigators can get a therapeutic response from patients that would otherwise undergo neurosurgery or will ultimately undergo neurosurgery.
CONDITIONS
Official Title
Interleaved TMS-fMRI in Ultra-treatment Resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 and 65 years
- Diagnosis of major depressive disorder or persistent depressive disorder with a moderate to severe major depressive episode confirmed by DSM 5.0
- Hamilton Rating Scale for Depression (HRSD-17) score of 18 or higher
- For ultra-treatment resistant depression (UTRD) group: depressive symptoms lasting 5 years or longer, resistance to more than 6 antidepressants and at least 1 adjunctive medication, failed at least 1 psychotherapy, and no response to at least 1 trial of esketamine, IV ketamine, ECT, or rTMS
- For milder treatment resistant depression (TRD) group: failure of at least 1 antidepressant medication of adequate dose and duration, and no prior neuromodulation treatment
You will not qualify if you...
- Contraindications to MRI
- Medical or psychiatric conditions that prevent study participation or where depression is not the main psychiatric issue
- History of psychosis
- Pregnancy
- Substance dependence in the past 6 months
- Active neurological disorders
- History of seizure disorder
- Cognitive impairment
- Unable to provide informed consent independently
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Actively Recruiting
Research Team
A
Anusha Baskaran, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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