Actively Recruiting
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
Led by University Medical Center Mainz · Updated on 2023-11-13
14
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University Medical Center Mainz
Lead Sponsor
A
ADVITOS GmbH München
Collaborating Sponsor
AI-Summary
What this Trial Is About
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal syndrome. The study will be performed in a regular non-ICU ward with a large experience in the use of the ADVOS therapy.
CONDITIONS
Official Title
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient can give consent
- Pre-existing liver disease with acute on chronic liver failure (ACLF) and hepatorenal syndrome (HRS)
- Age greater than 18 years
- Patient is treated at the University Medical Center Mainz
- Bilirubin level of 4 mg/dl or higher
- Indication for renal replacement therapy based on STARRT-AKI criteria (potassium 6 mmol/l in two separate tests; blood pH 7.2 or less or bicarbonate 12 mmol/l or less; respiratory failure from fluid overload)
You will not qualify if you...
- Age under 18 years
- Pregnancy
- Contraindications to ADVOS therapy
- Already started renal replacement therapy
- Contraindication for citrate anticoagulation
- Use of vasopressors with mean arterial pressure 50 mmHg or less
- Terminal cancer
AI-Screening
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Trial Site Locations
Total: 1 location
1
UNIVERSITÄTSMEDIZIN der Johannes Gutenberg-Universität Mainz I. Medizinische Klinik und Poliklinik
Mainz, Rhineland-Palatinate, Germany, 55130
Actively Recruiting
Research Team
J
Julia Weinmann-Menke, Prof.
CONTACT
P
Pascal Klimpke, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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