Actively Recruiting
Intermittent Hypoxia in Persons With Multiple Sclerosis
Led by Shirley Ryan AbilityLab · Updated on 2026-03-20
21
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
Sponsors
S
Shirley Ryan AbilityLab
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low levels of oxygen is called Acute Intermittent Hypoxia (AIH), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. Previous studies have shown that AIH is a safe and effective way to increase strength in persons with MS. Here the investigators aim to look at brain activation and ankle strength before and after AIH to gain a better understanding of how the AIH may improve strength in those persons with MS.
CONDITIONS
Official Title
Intermittent Hypoxia in Persons With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with relapsing form of multiple sclerosis (including relapsing-remitting and secondary-progressive MS)
- Expanded Disability Status Scale (EDSS) score between 3 and 6.5
- Motor Functional System Scale (FSS) score between 2 and 4
- Relapse free for at least 1 year
- Age 18 years or older and 75 years or younger
- Safe to undergo MRI scanning
- If using dalfampridine, must have been on the same daily dose for at least 2 months before screening
You will not qualify if you...
- Presence of active contrast-enhancing MS lesions or diffusion positive lesions indicating acute cerebrovascular disease on baseline MRI
- Uncontrolled hypertension (systolic between 85 and 140, diastolic between 90 and 55)
- History of epilepsy
- Chronic obstructive pulmonary disease
- Uncontrolled sleep apnea
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
A
Alexander Barry, MS, CCRC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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