Actively Recruiting
Intermittent Theta-burst Stimulation for Mild Cognitive Impairment
Led by The Hong Kong Polytechnic University · Updated on 2025-03-13
66
Participants Needed
2
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objectives of this study are to: 1. Evaluating the Impact of iTBS on Cognitive and Physical Functions: The investigators will investigate the efficacy of intermittent theta burst stimulation (iTBS) in patients with mild cognitive impairment (MCI), focusing on its effects on dual-task walking abilities, balance abilities, and cognitive function. 2. Comparing Clinical Efficacy Based on Stimulation Sites: The investigators will compare the clinical efficacy of iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) versus bilateral DLPFC stimulation. This comparison aims to directly examine potential differences in therapeutic outcomes based on the site of stimulation. 3. Investigating Neurophysiological Mechanisms: The investigators plan to elucidate the neurophysiological mechanisms underlying the improvements in cognitive functions and dual-task walking abilities in MCI patients facilitated by iTBS. This will be achieved using fNIRS neuroimaging of brain activity.
CONDITIONS
Official Title
Intermittent Theta-burst Stimulation for Mild Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 65 years or older
- Subjective cognitive decline with a Hong Kong Montreal Cognitive Assessment score between 19 and 25
- Independent in daily living activities and able to walk for at least 1 minute without assistance
- No serious visual or hearing impairments and able to complete study assessments
- Signed informed consent from patients and their families for iTBS treatment
You will not qualify if you...
- Contraindications to repetitive transcranial magnetic stimulation (rTMS)
- Cognitive problems caused by head injury or neurological diseases
- Severe physical illnesses such as speech disorders or unstable heart rhythm
- Currently critically ill with fever, infection, or organ failure
- Significant damage to the left frontal lobe of the brain
- Taking antidepressant or psychostimulant medications
- Unstable vital signs or organ failure
- Neuropsychiatric or mood disorders affecting test results
- Diagnosis of dementia
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, Hong Kong, 000000
Not Yet Recruiting
2
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, Hong Kong, 000000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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