Actively Recruiting
Intermittent Theta Burst Stimulation of the Prefrontal Cortex in Social Anxiety Disorder
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-03-12
100
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the therapeutic effects of intermittent theta burst stimulation on social anxiety disorder and to track physiological changes in the brain using electroencephalography (EEG). Eligible SAD participants, after voluntarily signing an informed consent form, will first complete basic information collection, baseline questionnaire completion, and a pre-treatment EEG data collection session lasting approximately 30 minutes (including resting-state and task-state recordings). Subsequently, participants will be randomly assigned to one of three groups (left iTBS group, right iTBS group, or sham stimulation group) to receive intensive treatment for one week (4 sessions daily for 5 consecutive days, totaling 20 sessions). Immediately following the intervention, the research team will conduct post-treatment EEG data collection and gather questionnaire assessments. Participants will also undergo follow-up visits at weeks 2, 4, 6, and 8 post-treatment to complete questionnaires and report any adverse events. All study procedures are strictly and safely conducted by trained professionals. Participation is entirely voluntary, and participants may withdraw unconditionally at any time during the study.
CONDITIONS
Official Title
Intermittent Theta Burst Stimulation of the Prefrontal Cortex in Social Anxiety Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Right-handed individuals aged 16 to 70 years
- Diagnosed with Social Anxiety Disorder (SAD) according to DSM-5 criteria
- Stable dosage of psychiatric medications for at least 4 weeks prior to enrollment if applicable
- Voluntary agreement to participate and provide written informed consent
You will not qualify if you...
- History of neurological disorders or severe somatic diseases such as seizures, central nervous system tumors, stroke, or brain aneurysms
- Diagnosis of other major psychiatric disorders including schizophrenia spectrum, bipolar disorder, depression, other anxiety disorders, obsessive-compulsive disorder, or somatic symptom disorders
- Presence of metallic implants in the head or neck
- Any contraindications to Transcranial Magnetic Stimulation (TMS)
- Previous history of TMS treatment
- Use of adequate doses of benzodiazepines for more than 2 weeks currently or in the past 4 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China, 310013
Actively Recruiting
Research Team
H
Han Yang, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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