Study of Patent Foramen Ovale Internal Microstructure and Its Link to Stroke, Transient Ischemic Attack, and Migraine Evaluating Transcatheter Closure Effectiveness and Long-Term Follow-Up

What this Trial Is About

Researchers are studying the internal structure of patent foramen ovale PFO, a heart condition linked to cryptogenic stroke, transient ischemic attack TIA, and migraine. The study aims to understand how the microstructure of PFO relates to these conditions and to assess the effectiveness of closing the PFO with a catheter-based procedure. It also includes examining asymptomatic PFO patients and analyzing blood samples to explore related metabolic features. The study includes three groups patients with PFO who have had a stroke or TIA and undergo closure, patients with PFO and migraine who also undergo closure, and asymptomatic patients with PFO who are followed for five years without closure. Blood samples are collected from various heart and vessel sites, and cardiac CT angiography CTA is used to evaluate device placement and shape. Participants will be monitored through clinical evaluations and blood tests, including metabolomics analysis from the right and left atrium. Researchers record symptoms during a test where blood is transferred between heart chambers. The main outcome measured is adverse events over five years after assessing the PFOs internal microstructure. This helps understand risks and guide treatment decisions for PFO-related conditions.

Internal Microstructure of Patent Foramen Ovale Related to Stroke