Actively Recruiting
International CRDS Registry
Led by Population Health Research Institute · Updated on 2026-02-05
500
Participants Needed
16
Research Sites
1362 weeks
Total Duration
On this page
Sponsors
P
Population Health Research Institute
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Calcium Release Deficiency Syndrome (CRDS) is a newly discovered genetic arrhythmia syndrome that confers a risk of life-threatening arrhythmias secondary to RYR2 loss-of-function. The International CRDS registry has been designed to facilitate large-scale evaluation of CRDS, including its phenotypic spectrum, approaches to risk stratification, and optimal treatment strategies.
CONDITIONS
Official Title
International CRDS Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of a rare RYR2 variant that is confirmed to be loss-of-function by in vitro testing
- Presence of a rare RYR2 truncating variant and/or large copy number variant involving the RYR2 gene
- Presence of a rare RYR2 variant that is confirmed to be neither loss- nor gain-of-function by in vitro testing
- Rare defined as gene variant prevalence less than 0.1% according to gnomAD
- RYR2 in vitro functional testing performed in a specified laboratory
You will not qualify if you...
- None specified
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
University of California
San Francisco, California, United States, 94143
Actively Recruiting
2
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
3
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
4
Garvan Institute of Medical Research
Darlinghurst, New South Wales, Australia, 2010
Actively Recruiting
5
Antwerp University Hospital
Edegem, Antwerp, Belgium, 2650
Actively Recruiting
6
Universitair Ziekenhuis Brussel
Brussels, Belgium, 1090
Actively Recruiting
7
University of Calgary
Calgary, Alberta, Canada, T2N 1N4
Actively Recruiting
8
Children's & Women's Health Centre of British Columbia
Vancouver, British Columbia, Canada, V6H 3N1
Actively Recruiting
9
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
10
London Health Sciences Centre - University Hospital
London, Ontario, Canada, N6A 5A5
Actively Recruiting
11
Montréal Heart Institute
Montreal, Quebec, Canada, H1T 1C8
Actively Recruiting
12
Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval
Québec, Quebec, Canada
Actively Recruiting
13
Aarhus University Hospital
Aarhus, Denmark, DK-8200 N
Actively Recruiting
14
CHU de Bordeaux
Bordeaux, New Aquitaine, France, 33404
Actively Recruiting
15
Shaare Zedek Medical Center
Jerusalem, Israel, 9103102
Actively Recruiting
16
City St George's, University of London
London, United Kingdom, EC1V 0HB
Actively Recruiting
Research Team
J
Jason D Roberts, MD MAS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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