Actively Recruiting
International Multicentric Study ARON-1
Led by Hospital of Macerata · Updated on 2025-11-26
1220
Participants Needed
1
Research Sites
290 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The ARON-1 Study is designed as an International Multicentric Retrospective Study to collect global experiences with the use of immuno-combinations in patients with metastatic RCC. Two Supplementary Studies (ARON-1α and ARON-1β) have been designed. The ARON-1α Supplementary Study has been designed to investigate for the presence of genomic signatures from tumor samples of patients treated with first-line immuno-combinations for advanced RCC. The ARON-1β Supplementary Study has been designed to charaterize the immune cell populations and assess their relationship with the clinical outcome of mRCC patients treated with first-line immuno-combinations
CONDITIONS
Official Title
International Multicentric Study ARON-1
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged >18 years
- Cytological or histologically confirmed diagnosis of clear cell or non-clear cell renal cell carcinoma
- Histologically or radiologically confirmed diagnosis of metastatic disease
- First-line treatment with nivolumab plus ipilimumab or nivolumab plus cabozantinib or pembrolizumab plus axitinib or pembrolizumab plus lenvatinib or avelumab plus axitinib or atezolizumab plus bevacizumab
You will not qualify if you...
- Patients without histologically confirmed diagnosis of renal cell carcinoma
- Patients without histologically or radiologically confirmed metastatic disease
- Patients treated with immuno-combinations not included in the list reported in the Inclusion Criteria Section
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ospedale di Macerata, UOC Oncologia
Province of Macerata, Macerata, Italy, 62100
Actively Recruiting
Research Team
M
Matteo Santoni, MD, PhD
CONTACT
G
Giulia Sorgentoni, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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