Actively Recruiting
An International Observational Study of Adults With Acute Infection
Led by University of Minnesota · Updated on 2026-04-02
1500
Participants Needed
47
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting an international observational study to better understand acute infections in adults who are hospitalized. This study focuses on collecting data and biospecimens to characterize various infectious diseases, including respiratory infections, infections outside the respiratory tract, established infectious diseases, and newly emerging infections. The aim is to gather information that will help identify risk factors, clinical features, and management strategies, as well as to aid in designing future clinical trials. Participants include adults admitted to the hospital with suspected or confirmed acute infections. There is no intervention or treatment being tested, as this is an observational study. The research involves monitoring patients during their hospital stay to collect vital data and samples related to their infection. Participants will be observed over time, with researchers assessing outcomes such as mortality by day 28, time to recovery, clinical improvement by day 7, organ support-free days, and organ failure scores. Data collection includes clinical assessments and biospecimen sampling to better understand infection progression and patient recovery. The study begins in August 2025 and continues through June 2027, allowing for extensive data gathering and analysis.
CONDITIONS
Brief Title
An International Observational Study of Adults With Acute Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Hospital admission or emergency department visit with anticipated hospital admission for suspected or confirmed acute infection
- Symptoms of infection started within the past 30 days
- Ability to provide informed consent or have a surrogate decision maker consent if unable
You will not qualify if you...
- Currently imprisoned (excluding quarantine for infectious disease)
- Receiving comfort care focused on end-of-life symptom management instead of life prolongation
- Expected inability or unwillingness to participate in study procedures
- Investigator determines participation is not in the patient's best interest
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 28 days
Participants who are hospitalized with acute infection are observed as part of the study.
Daily assessments during hospitalization up to Day 28
Trial Site Locations
Total: 47 locations
1
Banner University Medical Center Tucson
Tucson, Arizona, United States, 85719
Actively Recruiting
2
Stanford University Hospital & Clinics (Site 203-003)
Palo Alto, California, United States, 94305
Actively Recruiting
3
UCSF Medical Center (Site 203-001)
San Francisco, California, United States, 94143
Actively Recruiting
4
Orlando VA Medical Center (074-032)
Orlando, Florida, United States, 32827
Actively Recruiting
5
University of Illinois at Chicago (Site 008-012)
Chicago, Illinois, United States, 60612
Actively Recruiting
6
University of Kansas Medical Center (Site 080-044)
Kansas City, Kansas, United States, 66160
Actively Recruiting
7
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Not Yet Recruiting
8
Mayo Clinic (Site 054-001)
Rochester, Minnesota, United States, 55905
Actively Recruiting
9
University of Nebraska Medical Center (Site 080-045)
Omaha, Nebraska, United States, 68198-5400
Actively Recruiting
10
New York University Langone Health (301-013)
New York, New York, United States, 10016
Actively Recruiting
11
Mount Sinai Medical Center (Site 301-012)
New York, New York, United States, 11234
Actively Recruiting
12
Duke University (301-006)
Durham, North Carolina, United States, 27710
Actively Recruiting
13
Wake Forest Baptist Health (210-001)
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
14
Cleveland Clinic Foundation (Site 207-001)
Cleveland, Ohio, United States, 44195
Actively Recruiting
15
Vanderbilt University Medical Center (Site 212-001)
Nashville, Tennessee, United States, 37232
Actively Recruiting
16
UT Southwestern Medical Center (084-001)
Dallas, Texas, United States, 75390
Actively Recruiting
17
Intermountain Medical Center (Site 211-001)
Murray, Utah, United States, 84107
Actively Recruiting
18
West Virginia University Medicine (301-023)
Morgantown, West Virginia, United States, 26506
Actively Recruiting
19
Instituto Medico Platense (611-025)
La Plata, Buenos Aires, Argentina, B1900AVG
Actively Recruiting
20
Hospital General de Agudos JM Ramos Mejia (Site 611-001)
Buenos Aires, Argentina, C1221ADC
Actively Recruiting
21
Royal Prince Alfred Hospital (612-056)
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
22
St. Vincent's Hospital (612-002)
Sydney, New South Wales, Australia, 2010
Actively Recruiting
23
Westmead Hospital (Site 612-058)
Westmead, New South Wales, Australia, 2145
Actively Recruiting
24
Royal Brisbane and Women's Hospital (Site 612-055)
Brisbane, Queensland, Australia, 4029
Actively Recruiting
25
Monash Health (612-009)
Clayton, Victoria, Australia, 3168
Actively Recruiting
26
Austin Health (Site 612-020)
Heidelberg, Victoria, Australia, 3084
Actively Recruiting
27
The Alfred Hospital (Site 612-017)
Melbourne, Victoria, Australia, 3004
Actively Recruiting
28
The Royal Melbourne Hospital (612-025)
Parkville, Victoria, Australia, 3050
Actively Recruiting
29
Associaco Beneficente Siria - HCor (649-203)
São Paulo, São Paulo, Brazil, 04004-030
Actively Recruiting
30
CERMIPA (Site 403-001)
Abidjan, Côte d’Ivoire
Actively Recruiting
31
Rigshospitalet, CHIP (625-006)
Copenhagen, Denmark, 2100
Actively Recruiting
32
Hospices Civiles de Lyon (631-033)
Lyon, France, 69002
Actively Recruiting
33
Hospital St Louis (631-019)
Paris, France, 75010
Actively Recruiting
34
Klinik I fur Innere Medizin der Universitat zu Koln (622-008)
Cologne, Germany, 50937
Actively Recruiting
35
Evangelismos General Hospital (Site 635-020)
Athens, Attica, Greece, 10676
Actively Recruiting
36
3rd Dept of Medicine, Medical School (Site 635-022)
Athens, Attica, Greece, 11527
Actively Recruiting
37
Fujita Health University Hospital
Toyoake, Aichi-ken, Japan, 470-1192
Actively Recruiting
38
Japan Institute for Health Security
Tokyo, Japan, 162-8655
Actively Recruiting
39
Tan Tock Seng Hospital
Singapore, Singapore, 308443
Actively Recruiting
40
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Actively Recruiting
41
Seoul St. Mary's Hospital
Seoul, South Korea, 06591
Actively Recruiting
42
Hospital Universitari Germans Trias i Pujol (Site 626-003)
Badalona, Barcelona, Spain, 08916
Actively Recruiting
43
Chulalongkorn University and The HIV-NAT (Site 613-001)
Bangkok, Thailand, 10330
Actively Recruiting
44
MRC/UVRI & LSHTM Uganda Research Unit (Site 634-601)
Entebbe, Uganda
Actively Recruiting
45
Lira Regional Referral Hospital (Site 634-605)
Lira, Uganda
Actively Recruiting
46
Central City Clinical Hospital of Ivano-Frankivsk City Council (627-302)
Ivano-Frankivsk, Ukraine, 76018
Actively Recruiting
47
Royal Free Hospital (Site 634-006)
London, United Kingdom, NW3 2QG
Actively Recruiting
Research Team
R
Rebecca Schoenecker
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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