Actively Recruiting
International PPB/DICER1 Registry
Led by Children's Hospitals and Clinics of Minnesota · Updated on 2025-01-30
3400
Participants Needed
1
Research Sites
991 weeks
Total Duration
On this page
Sponsors
C
Children's Hospitals and Clinics of Minnesota
Lead Sponsor
W
Washington University School of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the treating institution. This study builds off of the 2009 study and will also seek to enroll individuals with DICER1-associated conditions, some of whom may present only with the DICER1 gene mutation, which will help the Registry understand how these tumors and conditions develop, their clinical course and the most effective treatments.
CONDITIONS
Official Title
International PPB/DICER1 Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Known or suspected pleuropulmonary blastoma or related thoracic tumor
- Known or suspected sex-cord stromal tumor including Sertoli-Leydig cell tumor and gynandroblastoma (males or females)
- Known or suspected DICER1-related conditions such as ovarian sarcoma, cystic nephroma, renal sarcoma, pineoblastoma, pituitary blastoma, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, and others
- Individuals with known or suspected DICER1 gene mutation regardless of diagnosed condition
- Informed consent provided by patient or parent/guardian (and assent/HIPAA consent when appropriate)
You will not qualify if you...
- Lack of appropriate consent for participation in the Registry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Minnesota
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
Research Team
K
Kris Ann P Schultz, MD
CONTACT
P
Paige HR Mallinger, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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