Actively Recruiting
Interpretation Bias as a Mechanism of Treatment Response in OCD
Led by Mclean Hospital · Updated on 2025-05-08
106
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I. Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.
CONDITIONS
Official Title
Interpretation Bias as a Mechanism of Treatment Response in OCD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults (over 18 years old) who are patients at the OCD Institute
- Able to complete a computer task lasting 20 minutes
- Consent to participate in the main OCD Institute study protocol
- Primary diagnosis of OCD confirmed by clinical diagnosis and a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score above 16
- Score above 131 on the Obsessive Beliefs Questionnaire-44 at admission
You will not qualify if you...
- Currently experiencing acute symptoms of psychosis
- Diagnosis of a psychotic disorder
AI-Screening
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Trial Site Locations
Total: 1 location
1
McLean Hospital
Belmont, Massachusetts, United States, 02478
Actively Recruiting
Research Team
M
Martha Falkenstein, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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