Actively Recruiting
Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Led by The University of Texas Health Science Center, Houston · Updated on 2025-06-26
60
Participants Needed
1
Research Sites
289 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inflammatory pathways.
CONDITIONS
Official Title
Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with systemic sclerosis-related constipation as defined in the study's first aim
- Patients with slow colonic transit (more than 20% radiopaque marks remaining in the colon 5 days after swallowing a Sitzmark capsule) or with rectal hyposensitivity
- Patients not yet receiving treatment for constipation or those on a stable constipation therapy for at least one month prior to TEA treatment
You will not qualify if you...
- Patients experiencing both diarrhea and constipation symptoms but without predominant constipation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
Z
Zsuzsanna H McMahan, MD, MHS (M-PI)
CONTACT
S
Sharvari R Kamat
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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