Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia.
Maya L Henry, H Isabel Hubbard, Stephanie M Grasso...
https://pubmed.ncbi.nlm.nih.gov/29718131Actively Recruiting
Phase Not Applicable
Age: 40Years +
All Genders
ID07219680
Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial
Led by Maya Henry · Updated on 2026-04-21
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Maya Henry
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a personalized, multi-component virtual speech language treatment program designed to improve communication and quality of life for adults with primary progressive aphasia (PPA) and their main communication partners. The study focuses on the feasibility, acceptability, and benefits of this telerehabilitation program, comparing immediate treatment to a waitlist control group. The trial includes English and/or Spanish speakers and aims to identify useful outcome measures and patterns of treatment response. Participants will receive speech language therapy sessions delivered by video that combine restorative, compensatory, and partner-focused communication strategies. Those in the waitlist control group will have an initial assessment followed by a 12 or 13-week waiting period before treatment begins. The immediate treatment group will start therapy right after assessment. Treatments include two specific multi-component programs: Multicomponent Lexical Retrieval Cascade Training and Multicomponent Video Implemented Script Training in Aphasia, both involving clinician-led sessions and independent practice alongside communication counseling with a study partner. During the study, participants and their partners will complete speech, language, and cognitive assessments, as well as questionnaires about communication abilities, daily functioning, and quality of life. Researchers will measure changes in spoken naming, script production accuracy, dyad conversation, and communication modality, along with secondary measures like aphasia impact and caregiver quality of life. Follow-up assessments occur three months post-treatment to monitor outcomes and participant experiences throughout the trial.
CONDITIONS
Brief Title
Intervention for Communication Quality of Life in Primary Progressive Aphasia
Who Can Participate
Age: 40Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary progressive aphasia (PPA) or PPA-plus
- MMSE score of 15 or higher and ability to produce single monosyllabic words intelligibly
- Speaks English, Spanish, or both languages
- Hearing and vision adequate for teleconference participation
- Has a study partner who can attend teleconference sessions
- Study partner willing to participate in assessments and treatment sessions
- Study partner speaks English, Spanish, or both languages
- Study partner's hearing and vision adequate for teleconference participation
- Participant and/or study partner has basic computer experience
You will not qualify if you...
- Other central nervous system or medical diagnosis that explains symptoms
- Psychiatric diagnosis that explains symptoms
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Treatment
Duration - 12 to 13 weeks
Participants receive behavioral interventions via in-person or teletherapy sessions, including biweekly sessions with a clinician targeting communication skills and strategy use, along with daily independent practice and meetings with a study partner for communication counseling and education.
Biweekly clinician sessions and 6 communication counseling sessions with a study partner
Follow-up
Duration - 3 months post-treatment
Participants are monitored for changes in communication abilities and quality of life after treatment completion.
1 follow-up visit
Trial Site Locations
Total: 1 location
1
University of Texas
Austin, Texas, United States, 78712
Actively Recruiting
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Research Team
H
Henry Lab Research Coordinator
G
Grasso Lab Research Coordinator
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Treatment for Word Retrieval in Semantic and Logopenic Variants of Primary Progressive Aphasia: Immediate and Long-Term Outcomes.
Maya L Henry, H Isabel Hubbard, Stephanie M Grasso...
https://pubmed.ncbi.nlm.nih.gov/31390290Investigating the utility of teletherapy in individuals with primary progressive aphasia.
Heather R Dial, Holly A Hinshelwood, Stephanie M Grasso...
https://pubmed.ncbi.nlm.nih.gov/30880927