Actively Recruiting

Phase Not Applicable
Age: 40Years +
All Genders
NCT07219680

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Led by Maya Henry · Updated on 2026-04-21

30

Participants Needed

1

Research Sites

69 weeks

Total Duration

On this page

Sponsors

M

Maya Henry

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish. The main questions the study aims to answer are: * Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners? * Do participants with PPA and study partners find treatment beneficial? * What patterns of treatment response are seen in participants? * Which outcome measures are most useful for evaluating changes in communication and quality of life? Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life. Participants will: * Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period. * Receive education and communication training together with their partner. * Complete speech, language, and cognitive assessments. * Complete questionnaires about communication abilities, daily functioning, and quality of life.

CONDITIONS

Official Title

Intervention for Communication Quality of Life in Primary Progressive Aphasia

Who Can Participate

Age: 40Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of primary progressive aphasia (PPA) or "PPA-plus"
  • MMSE score of 15 or higher
  • Ability to produce single monosyllabic words intelligibly
  • Speak English, Spanish, or both (bilingual speakers)
  • Hearing and vision adequate for teleconference participation
  • Availability of a study partner who can attend teleconference sessions
  • Study partner willing to participate in assessments and treatment sessions
  • Study partner speaks English, Spanish, or both
  • Study partner's hearing and vision adequate for teleconference participation
  • Participant and/or study partner have basic computer experience
Not Eligible

You will not qualify if you...

  • Other central nervous system or medical diagnoses that explain symptoms
  • Psychiatric diagnoses that explain symptoms

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

University of Texas

Austin, Texas, United States, 78712

Actively Recruiting

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Research Team

H

Henry Lab Research Coordinator

CONTACT

G

Grasso Lab Research Coordinator

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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