Actively Recruiting
Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
Led by Duke University · Updated on 2025-11-19
78
Participants Needed
2
Research Sites
324 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a research study to evaluate change in Quality of Life, as defined by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC C-30), from baseline to 1 month post treatment in two patient cohorts receiving Interventional Radiology Liver Directed Therapies or Hypofractionated Image-Guided Radiation Therapy.
CONDITIONS
Official Title
Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hepatocellular carcinoma diagnosed by histology/pathology or Liver Imaging Reporting and Data System (LIRADs 5) via CT or MRI
- Patient is 18 years or older
- ECOG Performance status of 0 to 2
- Child Pugh score A5, A6, B7, or B8
- Liver lesion size 5 cm or smaller
- Three or fewer liver lesions to be treated on protocol
- Lesions suitable for treatment with both Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy
You will not qualify if you...
- Child Pugh score B9 or Class C
- Fluctuating ascites
- Unable to complete baseline Quality of Life survey forms
- Receiving systemic therapy for hepatocellular carcinoma concurrently
- Previous liver radiation therapy unless approved by the principal investigator
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Durham Veterans Administration Health Care System (DVAHCS)
Durham, North Carolina, United States, 27705
Actively Recruiting
2
Duke Cancer Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
H
Heather Franklin
CONTACT
L
Linda Kaltenbach, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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