Actively Recruiting
Intestinal Flora and Immunity in Monoclonal Gammopathy Patients
Led by Zhujiang Hospital · Updated on 2024-09-19
300
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the characteristics of the gut microbiota and immune function status in patients with monoclonal gammopathy complicated by infection, and to analyze the correlation between the two.200 patients diagnosed with monoclonal gammopathy by MALDI-TOF MS were included, of which 100 had concurrent infections and 100 did not. An additional 100 healthy controls, matched for age and gender, were also enrolled.By comparing the composition of the gut microbiota and immune function markers (such as peripheral blood immune cell profiles and cytokine levels) between the patient groups and the control group, the study will evaluate the dysbiosis of the gut microbiota and abnormal immune status in patients with monoclonal gammopathy complicated by infection. The aim is to explore the correlation between the gut microbiome alterations and immune dysfunction, in order to provide a basis for further investigation of the underlying mechanisms.
CONDITIONS
Official Title
Intestinal Flora and Immunity in Monoclonal Gammopathy Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 years and older
- Monoclonal gammaglobulin negative by MALDI-TOF MS screening
- No symptoms of infection and normal infection markers (whole blood hs-CRP, serum IL-6, PCT)
- Sufficient remaining whole blood, plasma, and fecal samples available with relevant case information
You will not qualify if you...
- Previous diagnosis of intestinal tumor, irritable bowel syndrome, or inflammatory bowel disease
- Antibiotic therapy within the last month
- Severe systemic diseases including malignant tumors
- Insufficient sample volume or sample failure such as severe hemolysis, lipemia, or jaundice
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zhujiang Hospital of Southern Medical University
Guanzhou, Guangdong, China, 510280
Actively Recruiting
Research Team
N
Nianyi Zeng
CONTACT
H
Hongwei Zhou, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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