Actively Recruiting
Intestinal Transport of Microbial Metabolites in Chronic Kidney Disease
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-07-03
20
Participants Needed
1
Research Sites
630 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic kidney disease is associated with the accumulation of various metabolites, i.e., uremic retention solutes. Evidence is mounting that the colonic microbiome contributes substantially to these uremic retention solutes. Indoxyl sulfate and p-cresyl sulfate are among the most extensively studied gut microbial metabolites, and are associated with cardiovascular disease, chronic kidney disease progression and overall mortality. Mechanisms governing their intestinal uptake and metabolism, however, are currently unknown. The investigators aim to explore these transport characteristics in depth. Therefore, colonic biopsies will be sampled of patients with chronic kidney disease, analyzed and compared to available data of healthy controls. Insights in the mechanisms controlling intestinal transport and metabolism of indoxyl sulfate and p-cresyl sulfate is certainly relevant as it might lead to novel therapeutic targets in the treatment of chronic kidney disease.
CONDITIONS
Official Title
Intestinal Transport of Microbial Metabolites in Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �38 18 and �38 85 years
- Chronic kidney disease �3C= stage III (KDOQI), defined as an estimated glomerular filtration rate (MDRD) < 60 ml/min/m�B2 or need for dialysis therapy
- Scheduled for colonoscopy for diagnostic purposes
- Written informed consent provided
You will not qualify if you...
- History of gastrointestinal disease such as inflammatory bowel disease
- Prior colon surgery
- Recipient of a renal or other solid organ transplant
- Use of antibiotics or drugs known to affect intestinal transporters or enzymes within 2 weeks before colonoscopy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Leuven
Leuven, Vlaams Brabant, Belgium, 3000
Actively Recruiting
Research Team
S
Sander Derjongh
CONTACT
B
Bjorn Meijers, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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