Study of Aminophylline Instillation to Improve Ureteric Access Sheath Placement During Flexible Ureteroscopy for Kidney and Ureter Stones

What this Trial Is About

This research aims to evaluate whether intra-ureteric aminophylline instillation can help in placing the ureteric access sheath more easily during flexible ureteroscopy for kidney and ureteral stones. The study focuses on reducing ureteric injury rates and improving the procedures success in patients with stones smaller than 2 cm. Aminophylline is being studied because it relaxes smooth muscles and may reduce complications compared to traditional methods. Participants will be divided into three groups one receiving aminophylline instillation into the ureter, another using traditional ureteral dilators starting at 6 Fr and increasing to 12 Fr, and a third group receiving both aminophylline instillation followed by ureteral dilation. Aminophylline is applied at three points within the ureter using a catheter, with a 5-minute wait before proceeding. The study compares these approaches during flexible ureteroscopy. Throughout the study, researchers will track the success or failure of ureteric access sheath placement, the length of surgery, bleeding, any complications during or after the procedure, and stone clearance after three weeks using a CT scan. Participants will be monitored closely to assess these outcomes and ensure safety. The study is expected to run from March 2025 to February 2026.

Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure