Comparing Botulinum Toxin and Hyaluronic Acid Injections for Pain Relief in Adults 50 and Older with Knee Osteoarthritis

What this Trial Is About

Researchers are evaluating the effects of intra-articular injections of Botulinum toxin type A and hyaluronic acid on pain in adults aged 50 and older with knee osteoarthritis. Knee osteoarthritis is a common condition causing joint degeneration and chronic inflammation, leading to pain and disability. This study aims to compare these two treatments to understand their impact on pain relief and joint function. Participants will receive injections directly into the knee joint. One group will get 2 ml of hyaluronic acid injected three times weekly, while the other group will receive 100 units of Botulinum toxin type A diluted in 5 ml of saline, also three times weekly. Both treatments are administered via intra-articular injection. The study uses a randomized, double-blind, parallel design to compare the treatments. During the study, participants will be monitored over three months. Researchers will assess pain levels as the primary outcome, along with quality of life, the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC, and the Knee Injury and Osteoarthritis Outcome Score KOOS. These evaluations will help understand the treatments effects on knee function and patient well-being. The study is sponsored by Tanta University and participants will be followed until study completion in December 2026.

Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis