Actively Recruiting
Intraarticular Steroids, Saline and Occupational Therapy in People With CMC1 Osteoarthritis
Led by Diakonhjemmet Hospital · Updated on 2026-02-10
354
Participants Needed
6
Research Sites
256 weeks
Total Duration
On this page
Sponsors
D
Diakonhjemmet Hospital
Lead Sponsor
V
Vestre Viken Hospital Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
A placebo-controlled randomized controlled trial exploring the effect of intraarticular steroids, saline or an occupational therapy intervention in inflammatory carpometacarpal-1 osteoarthritis
CONDITIONS
Official Title
Intraarticular Steroids, Saline and Occupational Therapy in People With CMC1 Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 40 to 85 years
- Osteoarthritis in the target CMC-1 joint confirmed by radiographs or ultrasound
- Inflammation in the CMC-1 joint detected by ultrasound (grey scale synovitis grade 1-3)
- Pain score of at least 3 on a 0-10 Numeric Rating Scale at rest or during activities at both pre-screening and screening
- Assessed as eligible for treatment with Kenacort-T
You will not qualify if you...
- Use of thumb orthosis most days or structured hand exercises in the last 12 weeks
- Intraarticular injections in the target CMC-1 joint in the last 12 weeks
- More than 3 previous intraarticular corticosteroid injections in the target CMC-1 joint
- Use of oral, intramuscular, or intravenous steroids in the last 12 weeks
- Previous surgery of the target CMC-1 joint
- Planned hand surgery in the next 24 weeks
- Unwillingness to stop using oral or topical NSAIDs on the hands in the next 12 weeks
- Systemic inflammatory joint diseases or other conditions explaining hand pain better
- Diagnosis of fibromyalgia or psoriasis
- Infection, skin disease, or wounds at the injection site
- Serious comorbidities, cognitive dysfunction, substance/alcohol abuse, or other conditions making study adherence difficult
- Severe or uncontrolled infections
- Known allergy to Triamcinolone acetonide or its excipients
- Participation in another clinical study
- Use of digitalis glycosides
- Vaccination with live virus vaccines in the last 2 weeks
- Inability to speak or understand Norwegian
- Known pregnancy or planned pregnancy in the next 6 months
- Any condition that the investigator believes would prevent compliance with the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Nordlands Hospital
Bodø, Norway
Actively Recruiting
2
Haugesund Rheumatism Hospital
Haugesund, Norway
Actively Recruiting
3
Diakonhjemmet Hospital
Oslo, Norway
Actively Recruiting
4
Martina Hansens Hospital
Sandvika, Norway
Active, Not Recruiting
5
Stavanger University Hospital
Stavanger, Norway
Actively Recruiting
6
St Olavs Hospital
Trondheim, Norway
Actively Recruiting
Research Team
I
Ida Kristin Haugen, MD, PhD
CONTACT
M
Marthe Gløersen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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