Actively Recruiting
IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
Led by University Hospital, Basel, Switzerland · Updated on 2025-12-17
498
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this international, multi-center, randomized clinical trial is to compare two treatment options, early intracranial stenting and continued stent-retriever or aspiration based endovascular treatment, for stroke patients with a large vessel occlusion, who experienced failure of recanalisation after initial treatment due to intracranial atherosclerosis.
CONDITIONS
Official Title
IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical deficit with NIHSS score 6 for anterior circulation stroke or 10 for posterior circulation stroke
- Randomization expected within 24 hours of last seen well
- Occlusion in specific brain arteries including Internal Carotid Artery, M1, proximal/dominant M2 of Middle Cerebral Artery, Basilar Artery, or V4 segment of Vertebral Artery
- No recanalization after up to three endovascular treatment passes
- High likelihood of intracranial atherosclerotic disease as assessed by physician
- Age 18 years or older
- Occluded artery suitable for stenting as judged by physician
- No large infarct core (posterior circulation Alberta Stroke Program Early CT Score of 6 or above)
- Informed consent obtained or emergency consent criteria met
You will not qualify if you...
- Acute intracranial hemorrhage
- Pre-stroke modified Rankin Scale score of 3 or above
- Severe comorbidities likely preventing improvement or follow-up (cancer, substance abuse, dementia)
- Known clotting disorders or suspicion of hypercoagulant state
- Stroke occurring in hospital
- Contraindications for antiplatelet therapy
- Known serious allergies to radiographic contrast agents, nickel, titanium, or alloys
- Expected difficulties with follow-up due to geography
- Evidence of ongoing pregnancy
- Radiological evidence of mass effect or intracranial tumor (except small meningioma)
- Radiological evidence of cerebral vasculitis
- Vessel recanalization before randomization
- Participation in another interventional trial that could affect results
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Basel, Department of Interventional and Diagnostical Neuroradiology
Basel, Canton of Basel-City, Switzerland, 4031
Actively Recruiting
Research Team
A
Alex Brehm, PhD
CONTACT
M
Marios-Nikos Psychogios, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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