Actively Recruiting
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Led by Duke University · Updated on 2025-12-16
80
Participants Needed
2
Research Sites
247 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.
CONDITIONS
Official Title
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
- Willing to provide informed consent and participate in the study
- Ability to read and write English fluently
You will not qualify if you...
- Unwilling to provide informed consent
- Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
- Pregnant women
- Participants with active psychosis
- Participants with suicidal ideation
- Participants with substance abuse issues
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of California Los Angeles
Los Angeles, California, United States, 90024
Actively Recruiting
2
Duke University Health System
Durham, North Carolina, United States, 27705
Actively Recruiting
Research Team
G
Gabriela Vilchez
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here