Actively Recruiting
Intradermal Exosomes, Platelet-Rich Plasma, and Steroids for Post-Herpetic Neuralgia
Led by Zagazig University · Updated on 2026-05-04
45
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized controlled clinical trial will evaluate and compare the efficacy and safety of intradermal injection of exosomes, platelet-rich plasma, and corticosteroid in patients with post-herpetic neuralgia. Forty-five adult patients with dermatomal pain persisting for at least 90 days after herpes zoster will be enrolled from outpatient clinics. Participants will be assigned to one of three groups: intradermal exosome injection, intradermal autologous platelet-rich plasma injection, or intradermal triamcinolone acetonide injection. Each group will receive four treatment sessions every two weeks. Outcomes will include pain severity, neuropathic pain characteristics, quality of life, patient satisfaction, and adverse effects, assessed at baseline, at the final session, and during follow-up visits at 3 and 6 months after the last session.
CONDITIONS
Official Title
Intradermal Exosomes, Platelet-Rich Plasma, and Steroids for Post-Herpetic Neuralgia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with post-herpes zoster persistent dermatomal pain consistent with post-herpetic neuralgia for at least 90 days
- Male or female patients aged 18 years or older
- Willingness to comply with study procedures and attend follow-up visits
- Ability and willingness to provide written informed consent
You will not qualify if you...
- History of hypersensitivity to any of the study treatments
- Pregnancy
- Any type of skin infection involving the affected dermatome
- Immunocompromised patients, including those with cancer or HIV
- Patients with bone marrow aplasia
- Patients with known bleeding tendencies, platelet dysfunction, or thrombocytopenia (platelet count less than 150 × 10⁹/L)
- Regular use of anticoagulant or antiplatelet drugs
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zagazig University Hospitals
Zagazig, Zagazig, Egypt, 44519
Actively Recruiting
Research Team
M
mona Elradi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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