Actively Recruiting
Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma
Led by Carlo Contreras · Updated on 2026-03-10
36
Participants Needed
1
Research Sites
323 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase I trial investigates the effects of influenza vaccine in treating patients with stage I-IV melanoma. While intramuscular administration of influenza vaccine provides immunization against the influenza virus, giving influenza vaccine directly into the tumor (intralesional) may decrease the size of the injected melanoma tumor, or the extent of the melanoma within the body.
CONDITIONS
Official Title
Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 99 years
- Histologically confirmed cutaneous melanoma, stage I-III for Cohort 1 or stage IV for Cohort 2
- At least one biopsy-proven, palpable melanoma tumor of 1 cm or larger suitable for injection
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Adequate blood counts and organ function within 30 days prior to screening
- Women of childbearing potential must use effective contraception during the study and specified follow-up periods
- Women not of childbearing potential defined by menopause or surgical sterilization
- Negative pregnancy test for women of childbearing potential
You will not qualify if you...
- Known allergy or intolerance to influenza vaccine
- Need for systemic corticosteroids above 10 mg prednisone or other immunosuppressants within 14 days before study drug
- Active or suspected autoimmune disease
- Active brain or leptomeningeal metastases
- Diagnosis of ocular or mucosal melanoma
- Any melanoma therapy within 6 months except prior surgery
- Incarcerated individuals
- Pregnant or lactating women
- Unable to provide informed consent
- HIV positive patients not meeting stability and viral load criteria
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Actively Recruiting
Research Team
T
The Ohio State University Comprehensive Cancer Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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