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Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir
Led by Riphah International University · Updated on 2026-03-10
40
Participants Needed
2
Research Sites
12 weeks
Total Duration
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AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if injecting acyclovir (an antiviral drug) or vitamin D3 directly into skin warts works to clear them in people aged 12 and older with common, plantar, flat, or periungual (around the nail) warts. The main questions it aims to answer are: 1. Does intralesional acyclovir or vitamin D3 lead to complete clearance of warts by week 8? 2. Which treatment clears warts more effectively? 3. What side effects do participants have with each treatment? Researchers will compare acyclovir injections (Group A) to vitamin D3 injections (Group B), with 20 participants in each group, to see which treatment works better at clearing warts. Participants will: 1. Receive an injection directly into the wart every 2 weeks for up to 4 sessions 2. Have photographs taken of their warts before treatment and at each visit 3. Visit the clinic for checkups where the size and number of warts will be measured 4. Be followed for up to 3 months to check for wart recurrence and side effects
CONDITIONS
Official Title
Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 12 years and above with clinically diagnosed cutaneous warts
- Warts may be common, plantar, flat, or periungual
- Both treatment-nafve patients and those with recalcitrant warts can participate
You will not qualify if you...
- Pregnant or lactating women
- Immunocompromised patients
- Individuals with history of hypersensitivity to vitamin D3 or acyclovir
- Individuals receiving systemic immunosuppressive or antiviral therapy
- Patients with secondary infection at injection site
- Patients who had received any topical or destructive treatment for wart in previous three months
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Railway General Hospital, Railway Carriage Factory Rd, Railway Scheme 7, Rawalpindi
Rawalpindi, Punjab Province, Pakistan, 46000
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2
Riphah International Hospital, Islamabad Expy, Sector A DHA Phase 5, Islamabad
Islamabad, Pakistan, 44000
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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