Comparing Vitamin D3 and Acyclovir Injections to Treat Different Types of Skin Warts in People Aged 12 and Older

What this Trial Is About

Researchers are evaluating whether injecting acyclovir or vitamin D3 directly into skin warts can help clear them in people aged 12 years and older. The study focuses on common, plantar, flat, and periungual warts and aims to determine which treatment is more effective and what side effects each may cause. This is a Phase 4 clinical trial comparing the two treatments in a randomized, parallel design. Participants receive injections of either acyclovir or vitamin D3 directly into the wart every 2 weeks for up to four sessions. The dose depends on the size of each wart. Two groups of 20 participants each will receive these treatments to compare their effects. Injections are given at baseline and repeated every 2 weeks during the treatment period. During the study, participants will have photographs taken of their warts before treatment and at each visit. Clinic visits will include measurements of wart size and number. Researchers will follow participants for up to 3 months after treatment to monitor for wart recurrence and any side effects. The main outcome measured is complete clearance of warts by week 8, along with early recurrence and safety outcomes.

Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir