Actively Recruiting
Intramedullary Calcium Sulfate Antibiotic Depot
Led by Wake Forest University Health Sciences · Updated on 2025-12-15
497
Participants Needed
10
Research Sites
194 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients with a calcium sulfate antibiotic depot is better at preventing infection that the standard of care.
CONDITIONS
Official Title
Intramedullary Calcium Sulfate Antibiotic Depot
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years and older
- Type II or III open tibia fracture requiring definitive fixation with intramedullary nail
You will not qualify if you...
- Less than 18 years of age
- Allergy to vancomycin or tobramycin
- Hypercalcemia
- Unable to speak English or Spanish
- No email, phone, or other point of contact
- Pregnant and lactating women
- Prisoner
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Cedars-Sinai
Los Angeles, California, United States, 90048
Actively Recruiting
2
Atrium Health Navicent The Medical Center
Macon, Georgia, United States, 31201
Actively Recruiting
3
University of Kentucky
Lexington, Kentucky, United States, 40508
Not Yet Recruiting
4
Louisiana State University Health Sciences Center
New Orleans, Louisiana, United States, 70112
Actively Recruiting
5
Atrium Health Carolinas Medical Center
Charlotte, North Carolina, United States, 28204
Actively Recruiting
6
Atrium Health Cabarrus
Concord, North Carolina, United States, 28025
Actively Recruiting
7
Atrium Health Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
8
Pennsylvania State University
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
9
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Not Yet Recruiting
10
Valley Health
Winchester, Virginia, United States, 22601
Actively Recruiting
Research Team
C
Christine Churchill, MA
CONTACT
R
Rachel B Seymour, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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