Actively Recruiting
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Led by Peking University First Hospital · Updated on 2026-04-09
160
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain. Currently, there is a lack of clinical strategies to safely and effectively manage postoperative pain in children undergoing adenoid and tonsil surgery. Dexmedetomidine and esketamine can achieve appropriate sedation levels and alleviate postoperative pain when used in children. Both drugs can be administered intranasally, and their pharmacological effects complement each other, reducing side effects. This study aims to investigate whether intranasal administration of dexmedetomidine-esketamine combination can improve postoperative analgesia in children undergoing adenoid and tonsil surgery.
CONDITIONS
Official Title
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 3-7 years old
- Scheduled to undergo adenoidectomy and/or tonsillectomy under general anesthesia
- Provides written informed consent by the guardian
You will not qualify if you...
- Unsuitable for intranasal administration due to nasal diseases such as rhinitis, nasal polyps, or nasal congestion
- Diagnosed cardiovascular or respiratory diseases
- Communication barriers due to delayed neurological development or vision or hearing impairments
- History of traumatic brain injury or neurosurgery
- Abnormal liver or kidney function with biomarkers higher than twice the upper normal limits
- American Society of Anesthesiologists classification of III or higher
- Body mass index above the 95th percentile for age and sex
- Allergy to dexmedetomidine and/or esketamine
- Any other conditions deemed unsuitable for participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
T
Ting Ding, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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