Study of Intranasal Dexmedetomidine and Esketamine for Pain Relief After Adenoid and Tonsil Surgery in Children Aged 3 to 7

What this Trial Is About

Postoperative pain after adenoid and tonsil surgery is a significant problem for children, with about 75% experiencing severe pain. This trial studies whether a combination of two drugs, dexmedetomidine and esketamine, given through the nose can improve pain relief in children aged 3 to 7 undergoing these surgeries. The study is randomized and placebo-controlled to carefully evaluate the treatments effects. The trial involves two groups one receives an intranasal combination of dexmedetomidine and esketamine after anesthesia, and the other receives a placebo of normal saline in the same way. These drugs are chosen because they complement each others effects and may reduce side effects. The study tests whether this combination can provide better pain control after surgery compared to placebo. Participants will be monitored for pain intensity for up to 48 hours after surgery, with assessments including the area under the curve of pain scores. Sleep quality during the first three nights and the total amount of pain medication used within 48 hours will also be recorded. The study includes careful monitoring of participants and lasts through the early postoperative period to evaluate the effectiveness and safety of the treatment.

Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients