Actively Recruiting
Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery
Led by Peking University First Hospital · Updated on 2025-07-31
1988
Participants Needed
1
Research Sites
503 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.
CONDITIONS
Official Title
Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged over 50 years but under 90 years
- Diagnosed with resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery lasting more than 2 hours
- Agree to participate and sign informed consent
You will not qualify if you...
- Clinical exams show non-resectable lung cancer or surgery is only for biopsy
- Recurrent or metastatic lung cancer
- Previous cancer or cancer in other organs
- Long-term use of glucocorticoids or immunosuppressants due to autoimmune disease or organ transplant
- Uncontrolled hypertension (systolic >180 mmHg or diastolic >110 mmHg) or need for vasopressors to maintain blood pressure
- Persistent atrial fibrillation or acute cardiovascular events (heart attack, stroke, heart failure) within 3 months
- Severe liver dysfunction (Child-Pugh C) or kidney failure requiring dialysis
- Any other condition making participation unsuitable as decided by doctors or investigators
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
W
Wen-Wen Huang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
4
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