Actively Recruiting
Effectiveness of Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Patients Undergoing Open Rhinoplasty: A Randomized Controlled Trial
Led by Ain Shams University · Updated on 2025-05-13
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate how well a combination of ketamine and magnesium sulfate infusions during surgery controls pain after open rhinoplasty. The study focuses on managing postoperative pain, which is important for patient comfort and satisfaction. Both ketamine and magnesium sulfate target NMDA receptors but act differently, so their combined use may better control pain and reduce the need for opioid painkillers. Participants in the study will receive either a combination of ketamine and magnesium sulfate or a saline placebo during their rhinoplasty surgery. The ketamine dose includes a bolus followed by a constant infusion, while magnesium sulfate is given as a bolus and then a continuous infusion. The control group receives saline infusions. This comparison aims to assess the pain relief effects of the combined drugs during and after surgery. During the study, researchers will monitor total morphine use within 24 hours after surgery, time until first rescue pain medication, pain levels, heart rate, blood pressure, patient satisfaction, and any side effects. Monitoring occurs up to 24 hours postoperatively with heart rate and blood pressure tracked during surgery. The trial will help understand how this drug combination affects pain control and opioid use after rhinoplasty.
CONDITIONS
Brief Title
Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age from 18 to 65 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I - II.
- Scheduled for rhinoplasty under general anesthesia.
You will not qualify if you...
- Receiving analgesic or any medications within 48 hours before surgery.
- Drug addiction.
- Cardiovascular disease.
- Respiratory, renal, liver, metabolic, or neurological disease.
- Pregnancy or breastfeeding.
- Asthma.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 hours (duration of surgery)
Participants receive intraoperative infusions of ketamine and magnesium sulfate or saline during open rhinoplasty surgery to manage postoperative pain.
1 visit (in-person surgery day)
Duration - 24 hours postoperatively
Participants are monitored for pain control, opioid consumption, vital signs, and any adverse events for 24 hours after surgery.
Approximately 1 follow-up visit within 24 hours
Trial Site Locations
Total: 1 location
1
Ain Shams University
Cairo, Egypt, 11591
Actively Recruiting
Research Team
S
Sarah A Afifi, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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