Effectiveness of Using Ketamine and Magnesium Sulfate Together During Surgery for Pain Relief After Open Rhinoplasty in Adults Aged 18 to 65

What this Trial Is About

This research aims to evaluate how well a combination of ketamine and magnesium sulfate infusions during surgery controls pain after open rhinoplasty. The study focuses on managing postoperative pain, which is important for patient comfort and satisfaction. Both ketamine and magnesium sulfate target NMDA receptors but act differently, so their combined use may better control pain and reduce the need for opioid painkillers. Participants in the study will receive either a combination of ketamine and magnesium sulfate or a saline placebo during their rhinoplasty surgery. The ketamine dose includes a bolus followed by a constant infusion, while magnesium sulfate is given as a bolus and then a continuous infusion. The control group receives saline infusions. This comparison aims to assess the pain relief effects of the combined drugs during and after surgery. During the study, researchers will monitor total morphine use within 24 hours after surgery, time until first rescue pain medication, pain levels, heart rate, blood pressure, patient satisfaction, and any side effects. Monitoring occurs up to 24 hours postoperatively with heart rate and blood pressure tracked during surgery. The trial will help understand how this drug combination affects pain control and opioid use after rhinoplasty.

Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty