Actively Recruiting

Age: 18Years +
All Genders
NCT06545786

Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis

Led by Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology · Updated on 2025-04-08

265

Participants Needed

1

Research Sites

151 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Postoperative neurocognitive disorders (PND) are serious and common complications after surgery, especially in elderly patients. These disorders can affect cognitive functions for years, deteriorating quality of life and increasing hospital stays and medical costs. Diagnosing PND is challenging due to their varied manifestations, such as memory and attention problems, and the lack of standardized criteria and biomarkers. One well-studied form of PND is postoperative delirium (POD). According to the ICD-10, POD is an organic cerebral syndrome characterized by disturbances in consciousness, attention, perception, and other cognitive functions. Researchers suggest that POD development involves a combination of predisposing and precipitating factors. Electroencephalography (EEG) has been used in anesthesiology to assess anesthesia depth and intraoperative awareness. Modern EEG analysis methods, like spectral analysis, offer new ways to evaluate patients' neurophysiological states. Studies show that EEG monitoring can predict complications such as intraoperative stroke and delirium, particularly in cardiothoracic and neurosurgical operations. The relationship between EEG patterns and POD is not well understood. Specific EEG patterns may indicate the risk of POD, aiding in the identification of risk factors and prevention methods. This could help anesthesiologists and surgeons optimize their approaches, reducing the risk of cognitive complications.

CONDITIONS

Official Title

Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 65 18 years
  • Scheduled non-cardiac surgery of intermediate or high risk
  • General anesthesia using inhalational anesthetics
  • Provided informed consent to participate in the study
Not Eligible

You will not qualify if you...

  • Preoperative MMSE score less than 20 points
  • History of any mental illness
  • Use of psychotropic drugs within 1 month prior to inclusion
  • Presence of neuromuscular diseases
  • Neurosurgical procedures
  • Unable to undergo preoperative testing for any reason

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

City clinical hospital named after SS Yudin

Moscow, Moscow Oblast, Russia, 115446

Actively Recruiting

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Research Team

V

Valery Likhvantsev, PhD

CONTACT

L

Levan Berikashvili, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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