Actively Recruiting
Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis
Led by Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology · Updated on 2025-04-08
265
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative neurocognitive disorders (PND) are serious and common complications after surgery, especially in elderly patients. These disorders can affect cognitive functions for years, deteriorating quality of life and increasing hospital stays and medical costs. Diagnosing PND is challenging due to their varied manifestations, such as memory and attention problems, and the lack of standardized criteria and biomarkers. One well-studied form of PND is postoperative delirium (POD). According to the ICD-10, POD is an organic cerebral syndrome characterized by disturbances in consciousness, attention, perception, and other cognitive functions. Researchers suggest that POD development involves a combination of predisposing and precipitating factors. Electroencephalography (EEG) has been used in anesthesiology to assess anesthesia depth and intraoperative awareness. Modern EEG analysis methods, like spectral analysis, offer new ways to evaluate patients' neurophysiological states. Studies show that EEG monitoring can predict complications such as intraoperative stroke and delirium, particularly in cardiothoracic and neurosurgical operations. The relationship between EEG patterns and POD is not well understood. Specific EEG patterns may indicate the risk of POD, aiding in the identification of risk factors and prevention methods. This could help anesthesiologists and surgeons optimize their approaches, reducing the risk of cognitive complications.
CONDITIONS
Official Title
Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 18 years
- Scheduled non-cardiac surgery of intermediate or high risk
- General anesthesia using inhalational anesthetics
- Provided informed consent to participate in the study
You will not qualify if you...
- Preoperative MMSE score less than 20 points
- History of any mental illness
- Use of psychotropic drugs within 1 month prior to inclusion
- Presence of neuromuscular diseases
- Neurosurgical procedures
- Unable to undergo preoperative testing for any reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
City clinical hospital named after SS Yudin
Moscow, Moscow Oblast, Russia, 115446
Actively Recruiting
Research Team
V
Valery Likhvantsev, PhD
CONTACT
L
Levan Berikashvili, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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