Actively Recruiting
Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic (IDEA Network)
Led by Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology · Updated on 2025-04-08
265
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Postoperative neurocognitive disorders (PND) are serious complications that often occur after surgery, particularly in older adults. These disorders can affect cognitive functions like memory and attention for years, lowering quality of life and increasing hospital stays and medical costs. One common form, postoperative delirium (POD), involves disturbances in consciousness and cognition and is thought to arise from a mix of risk factors. Diagnosing PND is difficult due to varied symptoms and a lack of clear criteria or biomarkers. This observational study evaluates the use of intraoperative electroencephalography (EEG) to identify neurocognitive complications during surgery. Patients scheduled for intermediate to high-risk non-cardiac surgery under general anesthesia will have EEG recorded with a 16-electrode setup. Researchers aim to analyze EEG patterns, such as alpha rhythm power and burst suppression, to predict risks of postoperative delirium, early neurocognitive disorders, and silent brain infarction. Participants will undergo EEG monitoring during surgery and be followed for up to three years to assess cognitive outcomes and mortality. Researchers will collect data on intraoperative EEG signals and evaluate their prognostic value for postoperative complications. The study includes various cognitive and neurological assessments and tracks outcomes like delirium development and brain infarction, providing long-term insight into surgery-related brain health risks.
CONDITIONS
Brief Title
Intraoperative Diagnosis of Neurocognitive Complications Via Electroencephalographic Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63 18 years
- Scheduled non-cardiac surgery of intermediate or high risk
- General anesthesia using inhalational anesthetics
- Informed consent from the patient to participate in the study
You will not qualify if you...
- Preoperative MMSE score less than 20 points
- History of any mental illness
- Use of psychotropic drugs within 1 month prior to inclusion in the study
- Presence of neuromuscular diseases
- Neurosurgical procedures
- Inability to undergo preoperative testing for any reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of surgery
Participants undergo intraoperative electroencephalography (EEG) recording during their scheduled non-cardiac surgery to monitor brain activity.
1 intraoperative monitoring session
Duration - Up to 3 years
Participants are monitored postoperatively for neurocognitive complications such as delirium and silent brain infarction using EEG data and clinical assessments.
Periodic follow-up visits over several years
Trial Site Locations
Total: 1 location
1
City clinical hospital named after SS Yudin
Moscow, Moscow Oblast, Russia, 115446
Actively Recruiting
Research Team
V
Valery Likhvantsev, PhD
L
Levan Berikashvili, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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