Actively Recruiting

Phase Not Applicable
Age: 65Years +
All Genders
NCT05168280

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients

Led by Beijing Tiantan Hospital · Updated on 2025-03-03

420

Participants Needed

1

Research Sites

180 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Postoperative delirium (POD) is a common surgical complication. The incidence is 10% to 22% in neurological procedures, and advanced age is a risk factor for neurological procedures. Many studies have shown that dexmedetomidine(DEX) may reduce the incidence of delirium in non-cardiac surgery patients and elderly patients. However, there are few studies focus on the effect of DEX on POD in elderly patients undergoing neurosurgery. The purpose of this study was to investigate the effect of DEX on POD in in elderly patients undergoing craniotomy.

CONDITIONS

Official Title

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients

Who Can Participate

Age: 65Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients undergoing selective craniotomy.
  • Age 65 years or older.
  • Provide written informed consent.
Not Eligible

You will not qualify if you...

  • Surgery lasting less than 2 hours.
  • Refusal to give written informed consent.
  • Cognitive impairment before surgery (MMSE 26 or less or MoCA 22 or less).
  • Allergy to the study drug.
  • Body mass index less than 18 or 30 kg/m2 or more.
  • History of using psychotropic, anticholinergic, antihistamine, or dopaminergic drugs.
  • History of traumatic brain injury or previous neurosurgery.
  • Severe slow heart rate (less than 40 beats per minute), sick sinus syndrome, or advanced heart block.
  • Severe liver failure (Child-Pugh grade C) or kidney failure requiring dialysis.
  • Undergoing functional neurosurgery.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Beijing Tian Tan Hospital, Capital Medical University

Beijing, Beijing Municipality, China, 100070

Actively Recruiting

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Research Team

Y

Yuming Peng, MD,Ph.D

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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