Comparing Lidocaine and Dexmedetomidine Infusions During Abdominal Surgery to Reduce Postoperative Delirium and Improve Brain Oxygen Levels in Patients Aged 65 and Older

What this Trial Is About

Researchers are studying elderly patients aged 65 and older undergoing major abdominal surgeries to compare the effects of two medications, lidocaine and dexmedetomidine, given during surgery. The study aims to see how these drugs influence the occurrence of postoperative delirium, a common complication after surgery, and how they affect brain oxygen levels during the operation. This research is important because maintaining brain oxygen and reducing delirium may improve recovery in older patients. Participants will be randomly assigned to receive either lidocaine or dexmedetomidine through an intravenous infusion. Lidocaine is given as a 1 mgkg dose over 10 minutes before anesthesia, followed by a continuous infusion of 1.5 mgkg per hour until surgery ends. Dexmedetomidine is administered as a 0.5 mcgkg dose over 10 minutes before anesthesia, then infused at 0.3 mcgkg per hour during surgery. Both treatments are given intravenously during the operation. During the study, participants will be monitored for brain oxygen saturation levels using near-infrared spectroscopy throughout the surgery, which can last up to two hours. Researchers will also assess the incidence of postoperative delirium for three days after surgery, measure pain and opioid use in the first 24 hours after surgery, and record heart rate, blood pressure, and any adverse effects during and after the operation. This detailed monitoring helps evaluate how each medication impacts brain function and recovery in elderly surgical patients.

Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries