Actively Recruiting
Intraoperative Methadone for the Prevention of Postoperative Pain
Led by Brugmann University Hospital · Updated on 2025-02-07
80
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The pain felt after orthopedic surgery in the absence of adequate locoregional anesthesia is often insufficiently controlled, especially during the first 24 hours postoperatively. Methadone, due to its long half-life, may provide better pain control after orthopedic surgery when associated locoregional anesthesia cannot be performed. It may be impossible to perform loco-regional anesthesia in various contexts: patient refusal, pre-existing neurological impairment, infection at the injection site, coagulopathies, inability to cooperate, total language barrier, allergy to anesthetics, unavailability of equipment (ultrasound, etc.) or equipped room, lack of experience of nursing staff in performing the block and in the postoperative management of the patient. Intraoperative administration of methadone in these settings may be superior to sufentanil for pain control during the 24 hours post orthopedic surgery, and the pain control provided by methadone does not appear to imply a higher likelihood of adverse events related to opioids.
CONDITIONS
Official Title
Intraoperative Methadone for the Prevention of Postoperative Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- ASA physical status classification of 1 to 3
- Scheduled for elective partial or total hip or knee arthroplasty
You will not qualify if you...
- Patient refusal to participate
- Preoperative kidney failure (serum creatinine > 2 mg/dL or a 1.5-fold increase in baseline creatinine or GFR < 90 ml/min/1.73m2)
- Significant liver dysfunction (prothrombin time < 50% or threefold increase in liver transaminases)
- Known heart failure
- Preoperative hemodynamic instability requiring inotropes or vasopressors
- Known allergy to methadone or sufentanil
- Preoperative opioid use or history of opioid abuse
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Brugmann
Brussels, Belgium, 1020
Actively Recruiting
Research Team
R
Riccardo Mora, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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