Actively Recruiting
Perioperative Paravertebral Block to Reduce Postoperative Complications in Thoracic Surgery: An Observational Study
Led by Tongji Hospital · Updated on 2025-10-08
500
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the relationship between intraoperative paravertebral nerve blocks and the reduction of complications after thoracic surgery. This observational study includes both retrospective and prospective parts and focuses mainly on patients undergoing pulmonary and mediastinal thoracic surgeries. The goal is to explore how this nerve block might influence postoperative outcomes and identify related biochemical markers. Participants are divided into two groups: one receives a paravertebral nerve block under ultrasound guidance during surgery targeting the thoracic vertebrae related to the surgical site, using standard local anesthetics. The other group receives standard pain management without the nerve block, following usual institutional protocols. Both groups undergo thoracic surgery with standard anesthesia and monitoring. Retrospective data from previous surgeries with nerve blocks will also be analyzed. During the prospective part, researchers will collect biochemical markers like MMP3, neutrophils, leukocytes, PCT, and CRP around the surgery time. They will assess postoperative pain and cough scores, and record time to first flatus and defecation at 24 and 48 hours after surgery. Participants will be followed for 30 days to track complications. The study aims to correlate biomarkers with clinical outcomes to evaluate prognosis after thoracic surgery.
CONDITIONS
Brief Title
Intraoperative Paravertebral Block and Postoperative Complications
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants aged 18 years or older
- Scheduled for thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS) or Robotic-Assisted Thoracoscopic Surgery (RATS), including wedge resection, segmentectomy, lobectomy, or mediastinal surgery
- Signed informed consent obtained prior to study participation
You will not qualify if you...
- Patients who refuse to provide informed consent
- Anesthesiologists not trained in ultrasound-guided paravertebral block (PVB-US)
- History of ipsilateral thoracic surgery
- Conversion to open thoracotomy during the procedure
- Incomplete surgery due to disease progression or medical reasons
- Lost to follow-up or refusal of postoperative follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) prior to surgery for consent and eligibility confirmation
Duration - Day of surgery
Participants undergo thoracic surgery with or without an intraoperative paravertebral block (PVB) for perioperative pain management and complication reduction.
1 visit (in-person) on the day of surgery
Duration - 48 hours post-surgery plus up to 1 to 3 months for complication monitoring
Participants are assessed for pain, cough scores, gastrointestinal recovery, and biochemical parameters at 24 and 48 hours after surgery, with continued monitoring for postoperative complications.
Visits at 24 and 48 hours post-surgery plus follow-up contacts during 1 to 3 months postoperatively
Trial Site Locations
Total: 1 location
1
Tongji Medical College of HUST: Huazhong University of Science and Technology Tongji Medical College Tongji Hospital
Wuhan, Hubei, China, 430000
Actively Recruiting
Research Team
G
Guo jiateng Guo
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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