Actively Recruiting
Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2025-07-18
25
Participants Needed
1
Research Sites
308 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to investigate the safety of intraoperative radiation therapy (IORT) in patients with localized pancreatic cancer undergoing surgical resection after neoadjuvant chemotherapy and stereotactic body radiation therapy (SBRT).
CONDITIONS
Official Title
Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Resectable, borderline resectable, or locally advanced pancreatic cancer as defined by NCCN guidelines confirmed by imaging
- ECOG performance status of 0 to 2
- Provided written informed consent approved by Institutional Review Board
- Candidate for stereotactic body radiation therapy (SBRT) at Johns Hopkins University
- Received upfront multi-agent chemotherapy
- Candidate for surgical exploration at Johns Hopkins University
You will not qualify if you...
- Previous thoracic or abdominal radiation therapy
- Unable to receive SBRT at Johns Hopkins University
- Duodenal invasion seen on imaging excluding SBRT candidacy
- Tumor located in the pancreatic body or tail
- Unable to undergo Whipple surgical procedure
- Evidence of disease spread beyond the pancreas
- Any arterial reconstruction performed during surgery
- Currently enrolled in another investigational drug or device trial that interferes with this study
- Unable to comply with study requirements or follow-up schedule
- Women of childbearing potential or sexually active fertile men unwilling or unable to use contraception during the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
A
Amol Narang, MD
CONTACT
D
Dana B Kaplin, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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