Actively Recruiting
Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors
Led by Ondokuz Mayıs University · Updated on 2026-04-08
98
Participants Needed
1
Research Sites
34 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim is to compare the contributions of intraoral cryotherapy and supplemental lingual infiltration anesthesia to buccal infiltration anesthesia in mandibular incisor teeth with irreversible pulpitis in terms of anesthetic efficacy, and to evaluate the effect of adding intraoral cryotherapy to buccal anesthesia on anesthetic efficacy.
CONDITIONS
Official Title
Intraoral Cryotherapy on Anesthetic Efficacy in Mandibular Incisors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- Classified as ASA Physical Status I or II
- Symptomatic irreversible pulpitis in a single-rooted mandibular incisor tooth
- Preoperative pain score of 8 or higher on the Numerical Rating Scale and Wong-Baker FACES scale
- Positive response to cold test and electric pulp testing
- No periapical pathology on preoperative periapical radiograph
- No analgesic intake within 6 hours prior to treatment
- Ability to understand and complete pain assessment scales
- Willingness to provide written informed consent
You will not qualify if you...
- Age below 18 years or above 60 years
- Pregnancy
- Known allergy to local anesthetic agents
- Diagnosis of diabetes mellitus
- Presence of hypothyroidism
- Diagnosis of adrenal insufficiency
- Presence of Raynaud disease
- Uncontrolled diabetes (HbA1c >7%)
- Presence of periapical pathology detected radiographically
- Presence of sinus tract
- Presence of intraoral or extraoral swelling
- Teeth diagnosed with necrotic pulp
- Presence of referred pain from another tooth or anatomical structure
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ondokuz Mayıs University
Samsun, Atakum, Turkey (Türkiye)
Actively Recruiting
Research Team
C
Cangül Keskin, PhD DDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
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