Study of Intraosseous Morphine to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction Using Bone-to-Bone Autograft in Adults Aged 18 to 40

What this Trial Is About

Researchers are evaluating whether giving morphine through an intraosseous IO injection into the tibial tubercle can reduce pain and the need for opioids after anterior cruciate ligament ACL reconstruction surgery. This study focuses on patients undergoing ACL reconstruction using a bone-patellar tendon-bone BTB autograft, an area not previously studied for this type of pain management. The trial is a randomized, single-masked study sponsored by The Methodist Hospital Research Institute, aiming to improve post-operative outcomes. Participants will be randomly assigned to one of two groups. The intervention group will receive a 10mg morphine injection mixed with saline directly into the bone during standard ACL reconstruction surgery. The control group will receive the usual care without the intraosseous injection. This treatment occurs during the surgery and compares the effects of the IO morphine to standard care alone. During the study, patients will report pain levels using a post-operative symptom journal and the Lysholm Knee Survey at 2, 6, and 12 weeks after surgery. Researchers will also track opioid use during the first 2 weeks post-surgery. Additional assessments will include knee range of motion and activity levels measured before surgery and at follow-up visits. The total participation covers these evaluations and monitoring of pain and function over 12 weeks to understand the impact of the IO morphine treatment.

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction