Studying Pain Relief Effects of Different Doses of Intrathecal Dexmedetomidine With Bupivacaine in Male Adults Having Knee Surgery

What this Trial Is About

This research aims to compare how long pain relief lasts and the side effects after giving dexmedetomidine along with hyperbaric bupivacaine into the spinal area for patients having knee orthopedic surgery. The study evaluates different doses of dexmedetomidine to find the best balance of pain control and safety. Dexmedetomidine is known for targeting specific receptors that may enhance pain relief, and it is often used to reduce anesthesia and opioid needs during surgery. Participants will receive one of three doses of dexmedetomidine 4, 8, or 12 micrograms combined with 15 mg of hyperbaric bupivacaine injected into the spinal fluid. The study is randomized and double-blinded, meaning patients will be assigned by chance to a group without knowing which dose they receive. Each patient will receive the treatment during their knee surgery to test the effects of these different doses on pain relief duration. During the study, researchers will monitor how long it takes before patients need additional pain medication within 24 hours after surgery. They will also track vital signs like heart rate, blood pressure, breathing rate, and oxygen levels in the recovery room for up to 2 hours. These measurements will help assess both pain control and possible side effects. Overall, participants will be involved from surgery through the immediate recovery period, with detailed monitoring of their pain and safety.

Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery