Actively Recruiting
Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy
Led by Seoul National University Hospital · Updated on 2025-03-19
104
Participants Needed
1
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective randomized open-label noninferiority trial that compares intrathecal morphine injection and continuous wound infiltration after open pancreaticoduodenectomy.
CONDITIONS
Official Title
Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 19 years of age or older
- Scheduled for elective open pancreaticoduodenectomy or pylorus preserving pancreaticoduodenectomy
- Diagnosis of periampullary lesions
- Performance status with ECOG score of 0 or 1 at enrollment
- Able to provide written informed consent, understand study procedures, and complete questionnaires
- American Society of Anesthesiologists physical status I to III
You will not qualify if you...
- Allergy or hypersensitivity to fentanyl, ropivacaine, morphine, acetaminophen, or NSAIDs
- Cognitive impairment affecting use of patient-controlled analgesia or questionnaires
- Infection or abnormal anatomy of the abdominal wall or skin preventing catheter placement
- Contraindications to intrathecal injection such as coagulation disorders or ongoing anticoagulant use
- Major medical or psychiatric illness affecting treatment response
- History of chronic pain or chronic use of analgesics or psychiatric medications
- Severe liver or kidney disease
- Any other condition deemed inappropriate for study participation by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Seoul National University Hospital
Seoul, Seoul, South Korea, KS013
Actively Recruiting
Research Team
H
Ho-jin Lee, M.D., PhD.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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