Actively Recruiting
Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.
Led by Indiana University · Updated on 2026-02-13
142
Participants Needed
2
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. Investigators plan to compare their analgesic effectiveness at different postoperative time intervals.
CONDITIONS
Official Title
Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged 18 to 80 years
- Undergoing virgin or post-chemotherapy retroperitoneal lymph node dissection for primary testicular cancer at IU Health AAHC
- ASA physical status class 1, 2, or 3
- Body mass index (BMI) less than 50 kg/m2
You will not qualify if you...
- Any contraindication for neuraxial (spinal) analgesia
- Use of home methadone at any dose
- Physical, mental, or medical conditions that could affect accurate measurement of postoperative pain
- Known allergy to morphine, bupivacaine, acetaminophen, or methadone
- History of substance abuse including heroin or illegal drugs within the past 6 months
- End stage liver disease or end stage renal disease
- Remaining intubated after surgery
- Taking more than 30 mg per day of oral morphine equivalent at home
- Undergoing additional surgery with a different incision than standard laparotomy for RPLND
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Indiana Univeristy
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
Indiana University Hospital
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
L
Lyla S Farlow
CONTACT
A
Angie Plummer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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