Comparing Intrathecal Morphine and Local Bupivacaine for Recovery After Laparoscopic Hysterectomy in Women

What this Trial Is About

This research aims to compare two methods of pain relief after elective laparoscopic hysterectomy, a common surgery for benign gynecological conditions. The study evaluates the effects of intrathecal morphine versus trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response. Postoperative pain can arise from surgical trauma and peritoneal irritation, and effective pain management may improve comfort and recovery while reducing opioid use. Participants will be randomly assigned to one of two groups. The first group receives a single dose of 200 g intrathecal morphine injected into the spinal area before general anesthesia. The second group receives local anesthetic treatment with 0.25% bupivacaine infiltrated at trocar sites and sprayed intraperitoneally at the end of surgery, with total doses kept within safety limits. Both groups receive standard general anesthesia and additional medications as part of multimodal pain management. Participants will be assessed using the Quality of Recovery-15 QoR-15 questionnaire before surgery and 24 hours after. Pain levels, opioid use, time to mobilization and bowel movement, and side effects like nausea, vomiting, and respiratory issues will be monitored closely. Blood samples will be taken before surgery and 24 hours after to measure inflammatory markers. The study is blinded so that patients and care teams do not know which treatment was given. The trial aims to help optimize pain relief strategies for better recovery after laparoscopic hysterectomy.

Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy